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In clinical trials, average participants experienced 10-15% weight reductions of their initial body weight

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Its effects on glycemic control and body weight depend on sustained GLP-1 receptor occupancy over days to weeks, not on achieving specific peak concentrations ( Variability-sensitive pharmacodynamics (peak-driven, dose-critical effects): When effects are peak-driven or the therapeutic window is narrow, variability directly translates into clinical harm

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It highlights the advantages of nasal delivery systems, such as faster absorption and targeted effects, compared to traditional oral methods