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DCCT sub-analyses established that glycemic variability (not just HbA1c) predicts diabetic complication risk, making pramlintide's variability-reducing effects potentially more clinically important than the modest HbA1c change alone

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How to measure transcription-linked redox with rigor Methodologically, pair protein-centric readouts (redox proteomics of TF cysteines-Prx redox state) with compartment-targeted H 2 O 2 reporters in the nucleus or inner-nuclear membrane to capture flux and map footprints (3-nitrotyrosine, 8-oxoG) to link exposure with functional outcomes (Vaissier and Van Voorhis 2017

As NAc is also an important brain region associated with GLP-1-induced feeding suppression, further electrophysiological studies are necessary to explore the contribution of glutamatergic neurotransmission to endogenously released GLP-1-induced suppression of high-fat food intake in the VTA