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In the central nervous system, proglucagon and proglucagon-derived peptides (GLP-1, glucagon-like peptide-2, GLP-2, and oxyntomodulin, OXM) are only present in a small group of neurons in the nucleus tractus solitarius (24, 25)

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While GLP-1 receptor agonists have shown potential in mood stabilization, the GIP pathway may further enhance emotional and cognitive outcomes, potentially contributing to the observed reduction in suicide risk (25)