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The blood pressure evidence for L-Citrulline at supplement doses remains mixed overall, but a body of preliminary positive signals exists in adults with pre-hypertension or hypertension - consistently at doses in the grams-per-day range, not milligrams

A history of cardiovascular risk factors, such as hypertension, diabetes, and cigarette smoking, or a prior stroke may indicate a vascular contribution to dementia

doi: 10.1210/endo-45-3-296 31 LeungAMBravermanLE

If nausea is significant even with pyridoxine, the escalation may slow, holding at each dose for six or eight weeks instead of four

It's an adjunctive injection that supports fat metabolism and energy