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The short answer is that clinical trials have reported modest reductions in systolic blood pressure among people taking semaglutide, the active ingredient in Ozempic and Wegovy.[18] This is why the Ozempic blood pressure question keeps coming up as part of the wider cardiovascular picture, rather than as a stand-alone effect

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Many people choose to time their injections on Friday evenings so that the peak side effects occur during the weekend when they can rest