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Multiple CVB variants have been shown to induce cell degeneration, pyknosis, reduction of islet identity genes, and decreased insulin content and secretion in primary human islets cultured in vitro or transplanted into diabetic NOD mice (141, 143)

It is currently researched for among the following applications [14, 18]: Cell migration and tissue repair Formation of new blood vessels Maturation of stem cells Survival of various cell types Reducing inflammation TB-500 has poor oral bioavailability

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