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Injection site reactions occur in about 1 in 6 users, usually mild redness or swelling that resolves quickly

He said: Its better from an economic point of view to have a slightly less-effective drug but that a patient can persist over time, rather than a drug thats really effective but a patient who stops after a few months. The delicate nature of achieving equilibrium between efficacy and safety and therefore cost and adherence was underlined by Vrijens, who pointed to Pfizers recent decision to discontinue development of danuglipron (PF-06882961), an oral GLP-1 treatment, after a participant in one of the dose-optimization studies experienced potential drug-induced liver injury

Steady state is achieved by weeks 4-6 with weekly dosing

Higher-fat protein shakes may worsen nausea and delay gastric emptying further, potentially intensifying the sensation of fullness or discomfort