Some patients may experience a plateau or find that semaglutide works better for them due to their genetics, lifestyle, and other personal factors
Genolet R, Wahli W, Michalik L (2004) PPARs as drug targets to modulate inflammatory responses
When I meet with patients beginning GLP-1 therapy, I emphasize that this is not just a medication journey, says Jasdeep Saluja, MD, cofounder and chief medical officer of Aroga Lifestyle Medicine
Diabetes Care 47(8):13501359 Mather KJ, Mari A, Weerakkody G, Heise T, DeVries JH, Urva S, Coskun T, Milicevic Z, Haupt A, Thomas MK (2025) Greater improvement in insulin sensitivity per unit weight loss associated with tirzepatide versus semaglutide: An exploratory analysis
However, the sponsors analyses investigated oral semaglutide only in combination with metformin for second-line treatment, or in combination with metformin plus sulfonylurea for third-line treatment