VillanuevaEYalavarthiSBerthierCCHodginJBKhandpurRLinAMet alNetting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
No combination clinical trial has formally tested this synergy, but the mechanistic rationale is well-supported
This subtle but important mechanism enables the solution to remain stable and safe for extended periods within a sealed vial when aseptic handling practices are followed
Those that naturally contain vitamin B12 include lean red meats, poultry, fish, brewers yeast, and dairy products, such as milk, cheese, and yoghurt
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems