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Schalock 2014): Skin Raised, reddish patches covered with thick, silvery-white, shiny scales Reddening of skin can also be diffuse and widespread Pinpoint bleeding spots appear when scales are scraped off (Auspitz sign) Appearance of plaques at site of skin injury or infection (Koebner phenomenon) Teardrop-shaped lesions on trunk, limbs, and scalp after viral or bacterial (usually streptococcal) infection Pus-filled bumps or blisters on palms and soles Skin lesions may be itchy Systemic Fever, dehydration, and elevated white blood cell count may occur in severe cases muscle weakness uveitis (inflammation of part of the eye called the uvea) Other Nail changes pitting, discoloration, thickening, separation from nail bed Joint stiffness or pain, including inflammation or damage in psoriatic arthritis 6 Diagnosis The diagnosis of psoriasis is based on a physical examination of the skin, scalp, and nails

Concurrent ICV administration of GLP- 1 and GIP significantly increased neuronal activation and pro-opiomelanocortin expression in the arcuate nucleus of the hypothalamus

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