This review evaluates the antihypertensive potential of sodium-glucose cotransporter-2 inhibitors (SGLT2-i) and glucagon-like peptide-1 receptor agonists (GLP-1RA), particularly in patients with comorbid diabetes, HF, CKD or resistant hypertension
(1) intravenous administration with EMPA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS an hour after the administration with EMPA, (2) intravenous administration with LINA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS at an hour, (3) concurrent administration with EMPA (10 mg/kg) and LINA (10 mg/kg) followed by administration with PBS at an hour, and (4) intravenous administration with EMPA followed by administration with LINA at an hour (10 mg/kg)
Phentermine should be avoided by anyone with heart disease, uncontrolled hypertension, overactive thyroid, or a history of drug abuse
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