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Symptoms of MCAS may include: Rashes Hives Itching Heart palpitations Low blood pressure Headaches Chest pain Weight changes, including rapid weight loss or weight gain Digestive trouble, including diarrhea, nausea, and vomiting Loss of appetite or low appetite Anxiety Fatigue Vision changes Weakness Dizziness Mast Cell Activation Syndrome vs Histamine Intolerance You may notice the similarity between the symptoms of MCAS and histamine intolerance