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Physicians should establish baseline levels of IGF-1, fasting insulin, HbA1c, and a comprehensive metabolic panel prior to initiation

Thus, expectations for the overall magnitude of effect from a given agent might be modest when treating patients whose baseline A1c is 30 pioglitazone reduced HbA1c levels better than sitagliptin while in individuals with a BMI 90 canagliflozin lowered HbA1c better than sitagliptin while in individuals with an eGFR between 60-90 sitagliptin was more effective (13)