Keuthen NJ, OSullivan RL, Ricciardi JN, Shera D, Savage CR, Borgmann AS, et al
It is a 16amino-acid fragment from the C-terminal region of human growth hormone (often described as hGH 177191)
While the protection of normal cells against radiation-induced cell death by ebselen has been attributed to its ability to detoxify cellular/mitochondrial ROS through the GPx mechanism, the molecular mechanism contributing to its radio-sensitization effect in cancer cells is still not fully understood
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S100A7 lacks the ability of Ca 2+ -binding at the amino acid EF-hand motif, due to the absence of three amino acid residues and non-conserved substitution at position 12 of the EF-hand loop region ( 2+ -binding EF-hand ( Although S100A7 is constitutively expressed at relatively low levels in normal keratinocytes, its expression levels are dramatically increased in psoriatic lesions ( S100A7 exerts many functions, depending on its interaction with specific target proteins
