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3.3 I/R-induced AKI (I/R-AKI) AKI caused by renal I/R injury (I/R-AKI) emerges when blood circulation to kidneys suddenly decreases, with subsequent reperfusion generating an imbalance between oxygen and nutrient availability, harming endothelial cells and eventually progressing to kidney failure (Pan et al., 2021

A mandatory acclimation period of 24-48 hours was observed before data collection for analysis

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16-OHE 2 can be dehydrogenated to 16-hydroxyestrone (16-OHE 1 ), a metabolite that has been shown to bind covalently to the estrogen receptor via Schiff base formation