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Moreover, the modified GLP-1 RAs, which are designed to activate the GLP-1 receptor more effectively, have stronger neuroprotective efficacy than GLP-1 RAs used in clinical practice

Further questions remain regarding triplet therapy, including how it compares with monotherapy checkpoint inhibition and if the concurrent administration is superior to sequential therapy (NCT02224781)

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But I do think theres a place for orals in the market, both clinically and just efficacy-wise. The challenge, Verbeke explains, is in targeting the right patient population, particularly those for whom moderate weight loss and convenience may outweigh the maximal clinical effect