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GCGR (Glucagon Receptor) When co-activated with GLP-1R and GIPR in triple agonists such as Retatrutide , it boosts energy expenditure and fat oxidation, accelerating weight reduction

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This procedure involves inserting a colonoscope (a long, lighted tube with an attached camera) into your rectum and then into your colon

They were subsequently found to have a profound impact on weight which is why they are now being marketed as weight loss medications