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& Calissano, P
P., Lobisch, M., Schtte, K., & Gries, F
Purified water, DPG, glycerin, niacinamide, 1,2-hexanediol, butylene glycol, polyglycerin-3, hippophae rhamnoides water, acrylates/C10-30 alkyl acrylate crosspolymer, tromethamine, erythritol, pentylene glycol, 3-O-ethyl ascorbic acid, ethylhexylglycerin, polyglyceryl-4 caprate, adenosine, glutathione, hydrogenated lecithin, disodium EDTA, madecassoside, coptis japonica root extract, decyl glucoside, caprylyl glycol, ceramide NP, ascorbic acid, bisabolol, panthenol, tocopherol, arbutin, acetyl hexapeptide-8, hexapeptide-9, nonapeptide-1, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7
In IL-1-stimulated OA models, they upregulate SOX9 and COMP while suppressing ADAMTS4 activity, and micro-CT analysis shows 35% less subchondral bone loss
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