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Dernires recherches et recommandations cliniques (20222025) Les tudes rcentes (tudes STEP, SUSTAIN) confirment lefficacit du smaglutide sur la rduction du poids (jusqu 15 % en 68 semaines avec Wegovy) et sur la diminution des vnements cardiovasculaires majeurs chez le diabtique haut risque

Studies in animals have found that GLP-1 mediates 5 adenosine monophosphate-activated protein kinase (AMPK) phosphorylation by activating GLP-1R signaling, thereby regulating skeletal muscle remodeling and enhancing exercise tolerance, while glycogen synthesis, glucose uptake, type I muscle fiber proportion, and mitochondrial biosynthesis are enhanced in the skeletal muscles of GLP-1-AAV treated mice [19]

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Diabetes, Obesity & Metabolism, 27(6), 35233525

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