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Due to chronic inflammation, the secretion profile of adipokines in white adipose tissue also shifts, increasing the production of proinflammatory factors such as tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and leptin, while decreasing the secretion of anti-inflammatory interleukin-10 (IL-10) and adiponectin

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Hypoxia-inducible factor is critical for pathogenesis and regulation of immune cell functions in rheumatoid arthritis

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