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Expected FDA approval timeline is late 2026 to early 2027, with Health Canada approval likely following sometime after

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10.1016/j.ejphar.2011.05.038 31 IlicS.DrmicD.ZarkovicK.KolencD.CoricM.BrcicL.et al (2010)

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Some claudins act in part by controlling barrier function and paracellular permeability (e.g., claudin-2, -7 and -12), while others control barrier properties such as electrical tightness of the junctions (claudin-1, -3, -4, -5 and -8) (Barmeyer et al., 2015)