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This dual-agonist mechanism is what makes tirzepatide unique among all available weight loss medications, and it is the reason the weight loss results are so dramatically different from everything that came before

Unlike statins and other heart drugs, Wegovy is not a cholesterol-lowering medication, but it does have heart benefits, including lowering cardiovascular events by 20%

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It describes switching between semaglutide and tirzepatide as an evidence-based sequential step taken after optimizing within the current agent, so response and tolerability can be judged at each stage

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