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Patients and/or caregivers should discard any unused portion Patients and/or caregivers should store DUPIXENT by refrigerating at 36 F to 46 F (2 C to 8 C) in the original carton to protect from light If necessary, DUPIXENT may be kept at room temperature up to 77 F (25 C) for a maximum of 14 days

Insulin Insulin, a major negative regulator of adipocyte lipolysis, binds the insulin receptor (IR) and through the docking protein insulin receptor substrate 1 (IRS1) and IRS2 (116), activates the lipid kinase phosphatidylinositol 3-kinase (PI3-K), increasing production of PIP3 which stimulates the serine threonine kinase AKT/Protein kinase B (117) (Figure 2)