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This selective fat loss improves body composition without sacrificing lean muscle mass, a critical advantage over many weight loss interventions that result in both fat and muscle loss

Since then, hundreds of studies have examined its effects on tissue repair, inflammation, and healing

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Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells