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Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

Patients on the twice-daily exenatide were significantly less likely to experience treatment failure than those on the sulfonylurea glimepiride (41% versus 54%, HR 0.75, 95% CI 0.62 to 0.90,P=0.002), Baptist Gallwitz, MD, of Universitatsklinikum Tubingen in Tubingen, Germany, and colleagues reported online in The Lancet and at the American Diabetes Association meeting here

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Orforglipron (Eli Lilly) Orforglipron is a first-in-class, nonpeptide oral GLP-1 receptor agonist

(2016b)