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In the classic two-stage mouse skin carcinogenesis model, by which tumors are initiated by DMBA and promoted by repeated dosing with 12- O -tetradecanoylphorbol 13-acetate (TPA), the results showed that sulforaphane inhibited incidence and multiplicity of tumors during the promotion stage instead of the initiation stage 66

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Further Manifestations If the clinical manifestations mentioned above are left unaddressed, they may evolve into further issues (as noted as dark blue boxes in the above graphic)