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Common early effects include: Reduced hunger between meals Smaller portion sizes feel satisfying Fewer cravings for high-calorie or high-sugar foods A noticeable quieting of intrusive thoughts about food Visible weight loss takes longer

Accepting the first denial

For patients who tolerate the 2.4 mg dosage for at least 4 weeks and additional weight reduction is clinically indicated, the dosage may be increased to a maximum dosage of 7.2 mg subcutaneously once weekly

Semaglutide is sometimes compounded with B12 to support metabolic function and reduce the risk of deficiency, which can occur during active weight loss

Mechanism of cardiovascular benefit and weight loss In hypercholesterolemia, semaglutide is believed to reduce the progression of atherosclerosis via decreased gut permeability and decreased inflammation