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Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, Reynolds EC

Unlike full-length growth hormone, AOD9604 does not bind or activate the growth hormone receptor, enabling investigation of GH receptor-independent metabolic pathways

This piece is about which one is, and why the answer matters beyond a single peptide

Glossary AREs antioxidant response elements AARE amino acid response element ATF3 Activating transcription factor 3 ATF4 Activating transcription factor 4 ABCC5 ATP-binding Cassette Subfamily C Member 5 AIFM2 apoptosis-inducing factor mitochondria-associated 2 BRD4 Bromodomain-containing protein 4 BSO buthionine sulfoxide BACH1 BTB and CNC homology 1 CGL cystathionine -lyase BCAT2 Branched-chain amino acid aminotransferase 2 CREB cyclic adenosine monophosphate response element binding protein CHaC1 Gamma-Glutamylcyclotransferase 1 CDO1 Cysteine dioxygenase 1 CRC colorectal cancer CSCs colorectal cancer stem cells CoQ10 coenzyme Q10 DUB deubiquitinase DAZAP1 DAZ Associated Protein 1 EGFR Epidermal Growth Factor Receptor EP300 E1A binding protein P300 GSH glutathione FSP1 Ferroptosis suppressor protein 1 GPX4 glutathione peroxidase 4 GCL glutamate cysteine ligase GSS glutathione synthetase GCLC Glutamate-Cysteine ligase Catalytic Subunit GCLM Glutamate-Cysteine ligase Modifier Subunit GC gastric cancer GSTZ1 Glutathione S-transferase zeta 1 GDF15 Growth/differentiation factor 15 H3K9 H3 lysine 9 HSPA5 Heat shock protein A family member 5 HDACI histone deacetylase inhibitor HCC Hepatocellular Carcinoma HNF4 hepatocyte nuclear factor 4 HIC1 HIC ZBTB Transcriptional Repressor 1 HBV hepatitis B virus IKE imidazole ketone Erastin IPP isopentenyl pyrophosphate Keap1 Kelch-like ECH-associated protein 1 KRAS Kirsten Rat Sarcoma LOX lipoxygenase LOOHs lipid hydroperoxides LCN2 Lipocalin 2 Lipocalin 2 LUAD lung adenocarcinoma LONP1 Lon peptidase 1 LCN2 Lipocalin 2 Lipocalin 2 LSH Lymphoid-specific helicase MDA malondialdehyde MUC1 mucin glycoprotein Mucin 1 m6A N6 -methyladenosine MT-1G Metallothionein-1G MTOR mechanistic target of rapamycin kinase MCU mitochondrial calcium uniporter Nrf2 nuclear factor erythroid 2-related factor 2 NUPR1 Nuclear Protein 1 OTUB1 OTU deubiquitinase, ubiquitin aldehyde-binding 1 PE Piperazine Erastin p53 Tumor protein p53 PLOOH phospholipid hydroperoxide PUFAs polyunsaturated fatty acids PdPT palladium pyrithione complex PCDHB14 Protocadherin Beta 14 PSTK Phosphoseryl-tRNA kinase RSL3 RAS-selective lethal small molecule 3 RCD regulatory cell death ROS reactive oxygen species RRM2 Ribonucleotide reductase regulatory subunit M2 Rb retinoblastoma

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