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Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 ( n = 1,311) and STEP 2 ( n = 645)

Key mesolimbic reward areas, like the VTA and the NAc, are innervated by the GLP-1 producing neurons, potentially allowing hindbrain GLP-1 to modulate modulate reward behavior directly

Lancet 372:146372 Dodd S, Maes M, Anderson G, Dean O, Moylan S, Berk M (2013) Putative neuroprotective agents in major psychoses

By inhibiting gastric emptying, GLP-1 also improves blood sugar excursion, delays food absorption, and is therefore a regulator of satiety and appetite also through the hypothalamus (63)

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