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Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss

This form of Zepbound comes in a vial, which means patients must use a disposable syringe to inject it, rather than a self-injectable pen

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When activated, glucagon receptors increase energy expenditure through thermogenesis, promote lipolysis, which is the breakdown of stored fat, and enhance fatty acid oxidation in the liver

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