Higher risk groups include: People starting GLP-1 medicines for the first time People whose dose is increased too quickly People who eat large, oily, or very sweet meals People with type 2 diabetes using insulin or sulfonylureas People with previous pancreatitis People with gallstones or gallbladder disease People with severe digestive disorders People with gastroparesis People with kidney disease People with dehydration risk People with diabetic retinopathy People with a personal or family history of medullary thyroid carcinoma People with Multiple Endocrine Neoplasia syndrome type 2 People with active mood disorders or suicidal thoughts People planning surgery or procedures under anaesthesia Patients With Diabetes Vs Non-Diabetic Users People with diabetes may use GLP-1 medicines to improve blood sugar control and support weight management

This medication aids in appetite regulation and glucose metabolism while significantly contributing to sustainable weight management, particularly for individuals experiencing hormonal changes
IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
On the other hand, a vitamin B12 deficiency appears to cause a loss of appetite in some people, leading to weight loss rather than weight gain ( That said, the current evidence is too weak to suggest that a vitamin B12 deficiency has any strong or specific impact on weight be it weight gain or loss
L-carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial