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review at 4 mg, 9 mg, 12 mg Best For Mirrors current Phase 3 maintenance arms Approach Slow titration Duration Add 2-4 weeks per dose step when GI symptoms persist Review Point Each dose step Best For When nausea, vomiting, or diarrhea is hard to tolerate Trial protocols allowed participants to stay at the current dose for an extra 2-4 weeks when GI side effects were significant

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Thirdly, these results need to be interpreted with caution due to the potential differences in T1 and T2 relaxation times between different individuals and groups and their effects on neurochemical concentrations

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