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43 One RCT evaluated B12 alongside anti-depressants in patients with depression and moderately low B12 status (190300 ng/l) and found that 100% of those on B12, 1000 g per week i.m

However, significant weight loss is unlikely during this early period

10.1007/s11886-020-01282-5 50

However, findings on the impact of LEAP2 on food preference remain mixed, with some studies reporting inhibitory actions on the palatable food intake and others showing no significant changes [99, 100]

7 , e12139 (2021)