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In a hyperglycemic environment, TSPCs undergo aberrant differentiation due to elevated HMGB1 secretion, which regulates this process via the RAGE/catenin signaling pathway [61]

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Though it is not universal, a fair percentage of those on a ketogenic diet become L-carnitine deficient (absolute or relative), and demonstrate better control of epileptic events, as well as respond better to medication when supplemented with L-carnitine