Patients should contact their GP or NHS 111 if they experience symptoms that are severe, persistent, or significantly impact their quality of life, even if these symptoms are not listed as serious adverse effects
However, the challenge with current TRPV1 antagonists lies in their associated adverse effects, such as hyperthermia 24,25,26,27,28,29,30,31 and hypothermia 32,33,34 , caused by failures in thermoregulation
This means that if you go to your doctor with a problem, you will most likely leave their office with a prescription for a medication
Open communication with your healthcare provider will help you understand medical necessity criteria and gather documentation for prior authorization
Despite these limitations, the inclusion of large, high-quality randomised controlled trials supports the overall reliability of the findings