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Recent studies have shown that biotin also regulates immunological and inflammatory function

When diverse populations participate in clinical trials, researchers can better understand whether treatments work similarly across populations and support more equitable and preventative healthcare for all communities

Diagnostic evaluation may include: Detailed neurological examination assessing sensation, reflexes, and motor function Hemoglobin A1c measurement to evaluate recent glycemic control Vitamin B12 levels and methylmalonic acid (if B12 is borderline) Serum protein electrophoresis (SPEP) and immunofixation to screen for paraproteinemia Thyroid function tests, as hypothyroidism can contribute to neuropathic symptoms Comprehensive metabolic panel to assess renal and hepatic function Nerve conduction studies in selected cases with atypical features Management strategies focus on optimizing glycemic control, which remains the most evidence-based intervention for preventing and potentially improving diabetic neuropathy

Some arms of the phase 2 trials were dosing up weekly

Mazzo, M.L