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Other long-term toxicities Beyond the aforementioned target organ toxicities, long-term cohort studies have confirmed that platinum-based chemotherapy induces multiple delayed long-term adverse outcomes (manifesting years to decades post-chemotherapy, severely impairing cancer survivors long-term survival), including reproductive toxicity, cardiovascular toxicity, and elevated second primary neoplasm (SPN) risk

This action leads to a reduction in intracellular GSH levels, resulting in increased oxidative stress, which induces apoptosis and cell cycle arrest

The most common time to see side effects like these are when you initially start the medication or when you are increasing the dose

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