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[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed

The tolerability gap may be less significant in practice than the raw nausea percentages suggest

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Use 4-5 times 20 Gy in 2-day intervals (procedure is recommended by 27% of dermatologists)