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When does the risk outweigh the benefit

Side effects are a common part of any medication

Hypertension is the most common preventable risk factor for CVDs (including coronary heart disease, heart failure, stroke, myocardial infarction, atrial fibrillation, and peripheral artery disease), chronic kidney disease, and cognitive impairment, and also the main single factor for deaths and disability worldwide (133)

However, native GLP-1 is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and cleared renally, resulting in a plasma half-life of approximately 23 min [20, 21]

Arch Ophthalmol 124(2):178182 Etminan M et al (2012) Oral fluoroquinolones and the risk of retinal detachment