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The work also suggests that the GLP-1R uses the ER as a platform to reach and signal into many different cellular organelles, not just mitochondria

To mitigate these concerns, we included several proxy indicators in our propensity score matching, such as socioeconomic determinants (captured through ICD codes related to employment status, housing circumstances, and social environment), lifestyle counseling codes, and medication profiles that often correlate with health behaviors

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Their approach to weight management balances lifestyle changes with new medication to deliver strong, sustained clinical outcomes in a cost-effective manner