According to the latest literature available to the authors, ADSC-EVs ameliorate hepatic ischemiareperfusion injury [243], skeletal muscle injury [126, 244], diabetic [245, 246] or non-diabetic [247] erectile dysfunction, and thin endometrium-induced infertility [248], primarily through the activation of tissue regeneration characterized by enhanced cell proliferation, differentiation, angiogenesis, reduced apoptosis, and modulated production of cell factors regulating these processes
Completely different outcomes
Gastrointestinal adverse events were predominantly limited to initial dosing, while dose escalation resulted in lower discontinuation rates owing to these adverse events than among patients who remained on the starting dose
Wu Y (2024) Efficacy and safety of GLP-1 receptor agonists combined with SGLT-2 inhibitors in elderly patients with type 2 diabetes: a meta-analysis
A similar study was done on Sprague Dawley rats but with lower amounts of 0.0025, 0.01, 0.025, and 0.1 mg/kg/day