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The largest prospective cohort by Dao et al (2024) included 168 pregnancies and found no increased risk of congenital anomalies (CA) or pregnancy loss following first-trimester exposure

The best candidates for Semaglutide and Trizepatide injections are any adult with a BMI greater than or equal to 30 mg/kg alone or 27 mg/kg with at least one weight-related condition (e.g., high blood pressure, high cholesterol, Type 2 diabetes)

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Thus, the Cochrane review may have been somewhat limited by not just the number of women studied but the duration of clinical trials

Regular check-ins allow for dosage adjustments and side effect management