V., Machado, E
A detailed understanding of the distinct pathophysiological mechanisms and redox imbalances underlying each neurodegenerative disorder is crucial for advancing personalized therapeutic strategies, enabling interventions tailored to the specific cellular vulnerabilities and molecular drivers of each disease
In spinal cord tissues from patients with ALS, the expression of arachidonate 5-Lipoxygenase (ALOX5) and complement component 3 (C3) was markedly upregulated, accompanied by reduced GSH levels, elevated iron concentrations, and enhanced lipid peroxidation
Investigations focus on cell health proxies rather than clinical outcomes
Hulley S, Furberg C, Barrett-Connor E, Cauley J, Grady D, Haskell W, Knopp R, Lowery M, Satterfield S, Schrott H, Vittinghoff E, Hunninghake D, Group HR (2002) Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)