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In the case, the sisters modest weight improvement may benefit from female-specific hormonal environments (e.g., estrogen) that enhance GLP-1 receptor signaling, while the brothers limited response could be related to male-specific factors that blunt semaglutide-induced appetite suppression and energy expenditure regulation

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Hers includes a medical evaluation as part of the enrollment process to determine which medications and treatment plans are suitable for each individual

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In such cases, liver transplantation remains the only definitive cure