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Increased serum levels of human pancreatic polypeptide (HPP), gastrin, motilin, CCK, PYY, ghrelin, and also GIP, GLP-1, and GLP-2 have been reported either at baseline or postprandially in UC and/or CD (154, 163, 165168)

This dual mechanism produced even greater weight loss in clinical trials, with some participants losing over 25% of their body weight