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However, some individuals may experience initial gastrointestinal side effects when starting berberine

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Br J Pharmacol 179(4):557570 Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018a) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

If reactions persist for more than 48 hours, document them with photos to share with your healthcare provider