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GLP-1 and amylin have inhibitory effects on: (4) gastric emptying, (5) glucagon release, and (6) appetite

However, subjects on oral semaglutide had significantly higher adverse events (75% vs 68%) and premature discontinuation rates (15% vs 5%), predominantly from gastrointestinal side effects

PMID: 31446075

Gastric emptying

Sleep hygiene measures form the cornerstone of managing insomnia: Maintain a consistent sleep-wake schedule, even on weekends Create a cool, dark, quiet sleeping environment Avoid screens (phones, tablets, computers) for at least one hour before bedtime Limit caffeine intake, particularly after midday Avoid alcohol close to bedtime Engage in regular physical activity, but not within three hours of bedtime Establish a relaxing pre-sleep routine (reading, gentle stretching, meditation) Dietary considerations may also prove helpful