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Peyronies disease is diagnosed by the combination of a flat lump in the penis, a ben d with erections and pain

It is briefly mentioned in the Drug Interactions section to say the drug delays gastric emptying, and may impact absorption of concomitantly administered oral medications. It is also briefly mentioned in the Pharmacodynamics section, which describes how the drug works

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Lower thresholds likely exclude individuals without pauses in medication, whereas higher thresholds more likely relate to the actual dosage that individuals receive (i.e., those with no pauses but receiving low-to-intermediate doses are excluded with these thresholds)