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Glutamate drugs and pharmacogenetics of OCD: A pathway-based exploratory approach

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A large double-blind trial investigated whether semaglutide can help adults with obesity or those who are significantly overweight lose weight

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Amino acid imbalances, particularly in glutamate, methionine, glycine, and leucine, are frequently observed in GHD patients, contributing to muscle weakness, nitrogen imbalance, and metabolic inefficiencies (63, 64).Importantly, our study observed that biomarkers such as glycine, pyruvate, and leucine normalized following GH therapy, reflecting the well-documented metabolic effects of GH replacement in humans (20)