PMID: 27721485 Click image to see more details GLP-1 and GIP concentrations in the serum and mRNA levels of GCG and GIP
Even if it seems like a good idea that should work, if the evidence isnt there, then such a treatment should only proceed in a setting that can generate the essential evidence. Jeff Levin-Scherz, M.D., the population health leader for health and benefits in North America at Willis Towers Watson, noted that GLP-1 drugs have been in use since 2005
In clinical trials, patients on the highest dose (15 mg) lost around 20% of their body weight over 72 weeks
While the largest potential absolute benefit by race/ethnicity was observed in non-Hispanic White individuals, with 86,010 MACE (~ 14%), 21,123 cardiovascular deaths (~ 6%), 64,602 nonfatal myocardial infarctions (~ 25%), and 18,864 nonfatal strokes (~ 11%) prevented
The medicine had at one point been a key focus for many investors, with Pfizer talking up the potential of the obesity market and saying it had two potential experimental obesity medicines in development